Observations on the Inheritance of Sickle-Cell Hemoglobin and Hemoglobin C1

Observations on the inheritance of sickle-cell hemoglobin and hemoglobin C.

Intraerythrocytic Hemoglobin Crystals in Sickle Cell-hemoglobin C Disease.

Hemoglobin S gelation and sickle cell disease.

By William A. Eaton and James Hofrichter T HE FUNDAMENTAL cause ofsickle cell disease is the decreased deformability of the sickled red cell produced by gelation of hemoglobin S. Partial inhibition of gelation should therefore reduce clinical severity, while complete inhibition should result in a “cure.” These basic ideas have stimulated an enormous effort to understand the gelation process in ...

Further studies on hemoglobin C. I. A description of three additional families segregating for hemoglobin C and sickle cell hemoglobin.

Hemoglobin C and Sickle Cell Hemoglobin By JAIEs V. NEEL, NI.I)., PH.D., EUGENE KAPLAN, M.1),, AND WOLF W. ZUELZER, M.D. I x PREVIOUS COMMUNICATIONS the biochemical, geusetic, ansd (‘linsical aspects of a newly recognsized insherited abnormality of Isemogiohins were briefly descu ibed.n , 2 isew’ hemoglohius, which s ’as insdependenstly desigusated hemoglobins-Ill by Kaplats, Zuelzet’, ansd Xee...

Unusual low sickle cell hemoglobin level.